Guts and Grains

truth about grains in our food system

STORY AT-A-GLANCE

  • “Non-GMO” labeling does not mean chemical-free farming. These crops may still be treated with pesticides and herbicides. Many nonorganic grains are heavily sprayed with toxic pesticides like glyphosate just before harvest, a practice called desiccation
  • A recent study found glyphosate in 44 out of 46 organic and nonorganic gluten-free products tested, with some at alarmingly high levels
  • Glyphosate exposure can disrupt gut health by killing beneficial bacteria and promoting the growth of harmful bacteria. Consuming organic food has been linked to reduced cancer risk, according to a study published in JAMA Internal Medicine
  • The EPA’s acceptable daily intake for glyphosate is 7,000 times higher than European standards, raising concerns about regulatory oversight
  • Supporting organic and regenerative farming practices through consumer choices can help drive positive change in the food system

In an era where health consciousness is at an all-time high, many of us have become increasingly vigilant about the food we consume. We scrutinize labels, opt for organic produce when possible, and make concerted efforts to avoid processed foods. However, there’s a critical aspect of our food system that often flies under the radar … the production and processing of grains.

While many of us strive to make healthier choices, financial constraints often limit our ability to consistently purchase organic produce. (Check out the Environmental Working Group (EWG) “Clean 15,” the 15 produce items that had the lowest levels of pesticide residues, here).

However, when it comes to grains and grain legumes (wheat, oats, chickpeas, and more), the stakes are significantly higher. This overlooked component of our diet may be harboring more dangers than we realize, particularly when it comes to the use of pesticides and herbicides.

Unbeknownst to many consumers, numerous grains are heavily sprayed with toxic pesticides just before harvest, making the sourcing of organic grains, or at least knowing their origin, crucial for our health.

The Non-GMO Misconception

It’s important to note that organic agriculture isn’t without its flaws. While it generally involves fewer synthetic chemicals, some are still permitted. Moreover, organic farming often relies on tillage, a practice that involves mechanically manipulating the soil through plowing or cultivation. This process can be detrimental to soil health, degrading its structure, increasing erosion, and disrupting vital microbial populations.

A common misconception, however, is that “Non-GMO” labeling equates to chemical-free farming. In reality, this label merely indicates that the crops haven’t been genetically modified. It says nothing about the use of pesticides or herbicides during the growing process. This misunderstanding often leads consumers to believe they’re making a healthier choice when, in fact, they may still be exposing themselves to harmful chemicals.

While many people are aware that glyphosate and other toxic herbicides are used to control weeds, fewer realize that these chemicals are also employed as drying agents in some nonorganic farming operations — leading to higher levels of glyphosate in nonorganic products made from oats, wheat and other grains.1

This practice, known as desiccation, involves spraying crops with glyphosate 1 to 2 weeks before harvest to accelerate the drying process, allowing farmers to harvest sooner.2 It’s like giving crops a chemical spa day, except instead of coming out relaxed and rejuvenated, it comes out dead and potentially carcinogenic. Fancy!

The use of glyphosate as a pre-harvest desiccant has seen a dramatic increase in recent years. For example, even though wheat is not a GMO crop, glyphosate use on wheat has skyrocketed by 400% in the past two decades.3 This trend isn’t limited to wheat; it extends to a wide range of grains and legumes, including barley, oats, corn, soy, chickpeas, and more.

The practice of using glyphosate for crop desiccation can be traced back to Scotland in the 1980s. According to Charles Benbrook, Ph.D., farmers there struggled with uneven drying of wheat and barley crops. To solve this problem, they began using glyphosate to kill the crops shortly before harvest, accelerating the drying process.

And thus, the practice of spraying glyphosate on crops before harvest was born, soon spreading to other regions and crops. The use of glyphosate as a pre-harvest desiccant leaves chemical residues that are then processed into our food, significantly increasing our dietary exposure.4 While this practice isn’t universal, it’s particularly common in regions with short growing seasons and wetter harvests.

The Alarming Findings

Recent studies have revealed shocking levels of glyphosate in various grain products.5 The EWG conducted tests on popular breakfast cereals and snacks, finding significant amounts of glyphosate in many samples. The highest level was detected in Quaker Oatmeal Squares Honey Nut, which contained 2,837 parts per billion (ppb) of glyphosate — nearly 18 times the EWG’s benchmark.

Even more concerning, a study from March of this year6 tested 46 samples of organic and nonorganic gluten-free products for glyphosate and other pesticides.

The results were alarming: 44 out of 46 samples tested positive for glyphosate. The highest level was found in Banza Chickpea Pasta, at a staggering 2,693 parts per million (ppm), the highest amount ever recorded in human food by the lab conducting the study! (Also, some of the foods labeled as gluten-free in this study were found to contain gluten.)

banza

While glyphosate has been the focus of much research and public concern, it’s not the only chemical we should be worried about. The same study from March of this year that found high levels of glyphosate also identified 2,4-D, a component of Agent Orange, as the most prevalent pesticide in the samples. Products like King Arthur’s Gluten Free Flour and Milton’s Sea Salt Crackers were found to have the highest levels of pesticides.

Decimation of Our Guts

The health consequences of glyphosate exposure are becoming increasingly clear, with one of the most significant concerns being its impact on our gut microbiome.7

The suffix “-cide” in “herbicide” (and other similar terms like pesticide, fungicide, etc.) comes from the Latin word “caedere,” which means “to kill” or “to cut down.” Therefore, in the context of herbicide, “cide” indicates that the substance is designed to kill.

Glyphosate is designed to kill weeds and microorganisms in the soil, but our digestive systems contain trillions of microorganisms! Studies have shown that glyphosate can hinder the growth of beneficial gut bacteria while promoting the growth of pathogenic bacteria, leading to dysbiosis.8

“Glyphosate residues on food could cause dysbiosis, given that opportunistic pathogens are more resistant to glyphosate compared to commensal bacteria.”9

The Human Microbiome Project found that 732 out of 941 bacteria species in our gut have at least one copy of the gene that glyphosate targets. This means that 55% of our gut bacteria are sensitive to glyphosate, 38% are resistant, and 7% are unclassified.10 The potential for glyphosate to disrupt our gut health is, therefore, significant and concerning!

Regulatory Shortcomings

But don’t worry, folks. The Environmental Protection Agency (EPA) has got our backs. They’ve set the acceptable daily intake of glyphosate in our drinking water at a level that’s only … checks notes … 7,000 times higher than the European standard. Because nothing says “We care about public health” quite like allowing a generous helping of herbicide.

For food, the EPA in the United States has set the Acceptable Daily Intake (ADI) for glyphosate at 1.75 mg/kg body weight/day, which is significantly higher than the standards in Europe (0.5 mg/kg) and Canada (0.3 mg/kg).11 Even more alarming is that these standards only consider direct glyphosate toxicity, completely overlooking its potential impact on gut health.

Adding to the complexity of the issue is what researchers call the “cocktail effect.” While glyphosate is the active ingredient in many herbicides, crops are often treated with a mixture of agrochemicals. The synergistic effects of these chemical combinations are largely unknown and unstudied, particularly concerning their impact on the gut microbiome. This gap in our understanding poses significant risks to human health!

Another often-overlooked aspect of pesticide exposure is the cumulative effect. Even if individual foods contain “safe” levels of pesticides relative to the EPAs standards, regular consumption of multiple foods with residues can lead to a significant total exposure over time. This cumulative effect is rarely considered in regulatory decisions or public health guidelines.

“While glyphosate is the active ingredient, food crops are desiccated with GBH, which contain compounds in addition to glyphosate. Complicating matters further is the fact that most GBH are proprietary and their ingredients and the relative percentages are unknown.

This ambiguity poses a significant challenge for researchers as they do not know what they’re working with, the amount present and the synergistic effects of these chemicals when combined. Additionally, crops are often treated with a proverbial ‘cocktail’ of agrochemicals, including other herbicides, in addition to glyphosate and GBH.

The cytotoxic effects of glyphosate appear to increase when combined with other herbicides, including Paraquat … This synergistic phenomenon suggests that relatively low glyphosate residues within our food supply could have serious consequences when combined with other commonly used agrochemicals.”12

As awareness of glyphosate’s potential harm grows, some farmers are turning to alternative chemicals like Dicamba. However, this shift doesn’t necessarily represent an improvement in terms of health or environmental impact. It merely replaces one potentially harmful chemical with another, perpetuating a cycle of chemical dependency in agriculture.

It’s crucial to understand that the widespread use of toxic chemicals in farming is not the fault of individual farmers, but rather a result of the broken agricultural system shaped by government policies and industry influences over decades. Farmers often find themselves caught in a challenging situation, pressured by economic realities, market demands, and agricultural policies that have long favored high-yield, chemically intensive farming practices.

The current system, largely shaped by government subsidies, research funding priorities, and regulatory frameworks, has created an environment where conventional, chemical-dependent farming is often the most economically viable option for many farmers.

Additionally, years of specialized education and industry messaging (and propaganda) have reinforced these practices, making it difficult for farmers to transition to alternative methods without significant support and systemic change. Many farmers are simply trying to survive in a system that wasn’t designed with long-term environmental and health consequences in mind.

The Way Forward

The prevalence of glyphosate in our food system is alarming, with the chemical even being detected in women’s breast milk,13 indicating its ability to bio-accumulate in the human body.

But we can reduce our exposure significantly by paying attention to where our food comes from (ESPECIALLY when it comes to grains). And the research now supports that reducing consumption of foods high in glyphosate can lead to significant health improvements.

A review conducted by the University of Washington found that agricultural workers who used glyphosate extensively were 41% more likely to develop Non-Hodgkin’s lymphoma during their lifetime compared to those who used it infrequently or not at all.14

Furthermore, a major study published in JAMA Internal Medicine revealed a significant reduction in cancer risk for individuals who consumed a diet rich in organic food.15

Conclusion

While sourcing organic produce isn’t always feasible, it’s crucial for consumers to be more aware of where their grains (wheat, oats, corn, rice, barley, chickpeas, etc.) or grain by-products (bread, baked-goods, cereal, crackers, etc.) come from. Just as many people advocate knowing your meat’s origin, the same principle should apply to grains and cereal crops.

It’s important to further emphasize that simply eliminating soy or wheat from one’s diet and choosing “gluten-free” doesn’t guarantee the elimination of glyphosate exposure, as many other nonorganic crops are desiccated before harvest.

For example, if you were regularly buying the Banza Chickpea pasta because you thought it was a healthier gluten-free option, you were unknowingly significantly increasing your glyphosate exposure.

Now, I know we’ve covered a lot of ground here, and you might be feeling a bit overwhelmed. You might even be eyeing your morning toast with suspicion, wondering if it’s plotting against you!

But remember, knowledge is power! And in this case, it’s the power to make better choices about what you put in your body. This will not be a “top-down” effort, as the government does not put public health first.

Instead, change will be from the “bottom-up” through consumer demand. Since public health is secondary to corporate interests, it is on us as consumers to educate ourselves about these issues, ask questions, and make informed choices about the foods we consume.

Organic is the better option relative to non-GMO for grains. However, the ideal solution would be sourcing from regenerative farms, although these can be harder to find.

Regenerative grain production involves minimal or zero chemical use and instead focuses on building soil health to produce healthy crops. This approach not only reduces chemical exposure but also improves soil health since tillage is not employed.

Supporting organic and regenerative farming practices and demanding transparency in food production from farmers, cooperatives, and food companies are crucial steps towards a healthier food system. It really is on us!

In the end, the question isn’t always just about what we eat, but about how our food is produced. By paying attention to these often-overlooked aspects of our food system, we can take control of our health and contribute to a more sustainable future for agriculture.

You can make a difference by supporting organic and regenerative farmers. Think of it as voting with your fork (or spoon). Every time you choose an organic grain product, you’re essentially voting against the chemical-based conventional farming system.

from:    https://articles.mercola.com/sites/articles/archive/2024/07/30/truth-about-grains-in-our-food-system.aspx?ui=f460707c057231d228aac22d51b97f2a8dcffa7b857ec065e5a5bfbcfab498ac&sd=20211017&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20240730_HL2&foDate=true&mid=DM1608961&rid=85574406

Guts, Enzymes, Serotonin, And Health — And a note about DNA

How Endotoxins and Estrogen Can Wreck Your Health

Analysis by Dr. Joseph MercolaFact Checked
  • Endotoxin and mycotoxins play an important role in many chronic degenerative diseases
  • Endotoxin, also known as lipopolysaccharide (LPS), is produced by gram-negative bacteria in your gut. When complex carbs aren’t digested in your stomach, they travel down to the intestine where they feed these bacteria, and as the bacteria grow, multiply and die, the bacteria release LPS, which can result in leaky gut, allergic reactions, organ dysfunction and even sepsis
  • Endotoxin also catalyzes metabolic reactions that convert tryptophan in your gut to serotonin. You do not want high levels of serotonin because it’s antimetabolic. It suppresses your body’s ability to create energy in the electron transport chain, so you become tired and fatigued, your metabolic rate slows and you gain weight
  • Estrogen excess can produce symptoms that are identical to endotoxin toxicity, and an estimated 30% of endotoxin cases are misdiagnosed, and are related to excess estrogen
  • Estrogen is one of our biggest toxic threats today, as both men and women are exposed to high amounts of estrogenic compounds in their diet and environment. Most already have too much estrogen, which is a major driver of certain cancers

Today’s interview features Kashif Khan, founder and CEO of The DNA Company, which analyzes your DNA and keeps your data private, unlike 23andMe and other companies that sell your genetic data to third parties like drug companies.

Our discussion here is not about DNA analysis, however, but rather endotoxin and mycotoxin, which can play an important role in many chronic degenerative diseases, and estrogen excess, which can produce symptoms identical to endotoxin. Khan is quite knowledgeable in this area.

“The biggest area where we’re seeing a flood of people coming in, is in the female health world,” Khan says. “Not that this is an answer for everybody, but what we’re seeing is that all these women are concerned about how they feel and it’s been labeled as an endotoxin problem.

We’re diving in and seeing that about 30% of them are misdiagnosed. It’s actually an estrogen problem. They have the same symptoms, same complaints, same everything. We know that endotoxins are a concern, and so that concern is being taught in functional medicine … Mycotoxins are also being misdiagnosed.

So, a big area we end up supporting and helping is actually looking at the hormone pathway and seeing what toxic hormones are people making. This is one piece of the conversation, it’s one slice, but it’s a big slice where the most help is needed …

Whether it’s men producing DHT that’s causing inflammation, or women producing 4-hydroxy estrogen or 16-hydroxy estrogen as this constant trickle of inflammation, representing the same symptoms, same everything, they’re just not getting help. They’re not getting fixed because that’s what’s actually driving the symptoms. And we keep seeing this over and over again.”

What Are Endotoxin and Mycotoxin?

Endotoxin, also known as lipopolysaccharide (LPS), is produced by gram-negative bacteria in your gut. When complex carbs aren’t digested in your stomach, they travel down to the intestine where they feed these bacteria, and as the bacteria grow, multiply and die, the bacteria release LPS, which can result in leaky gut, allergic reactions, organ dysfunction and even sepsis.

Endotoxin also catalyzes a series of metabolic reactions that convert tryptophan in your gut to serotonin. Most people think serotonin is good, but mostly, especially higher levels, it is not good for your health. You do not want high levels of serotonin because it’s an antimetabolite.

This means it suppresses your body’s ability to create energy in your mitochondria in the electron transport chain, so you become tired and fatigued, your metabolic rate slows and you gain weight.

While endotoxin typically is related to gram-negative bacteria, mycotoxin is generated by things like fungi and yeast, such as candida. Mycotoxin such as mold can also have a volatile organic compounds (VOCs) aspect to it. This is the smell or odor, which can make you sick all by itself.

Toxic Reservoirs Must Be Addressed

As explained by Khan, when it comes to endotoxin and mycotoxin, it’s important to realize that you likely have a reservoir of toxin-producing bacteria in your system that will continue causing problems for as long as you keep feeding them. What’s more, within the metabolic pathway of endotoxin, a gene expression change occurs that is triggered by nutrition or environment.

“That triggers production of enzymes and proteins like amylase and cellulase to then convert the fuel that they’re consuming into the building blocks of the ensuing toxins, like mycotoxins, for example,” Khan explains.

“So, you have this internal combustion engine of making more and more, and the genes are being triggered in the actual toxin to make more of the outcome of this inflammatory toxin. And so, it’s happening on the inside too. That’s what people don’t get.

You’re binding and clearing, but if you’re not dealing with innate fungal overgrowth or toxin overload, you’re still making more of it. We often look at the gut as the source of what you need to work on, but it’s not just about what’s coming in. It’s also what you make on the inside. People need to think about that.”

How to Address Endotoxin and Mycotoxin

To address this vicious cycle, you need to heal and seal your gut. Beneficial bacteria, such as bifidobacteria and lactobacillus, and beneficial yeast like Saccharomyces boulardii can help repopulate your gut with beneficial microbes.

Saccharomyces boulardii is frequently prescribed by knowledgeable physicians to individuals who need to take antibiotics, because the saccharomyces are not killed by antibiotics. Intermittent use of binders such as activated charcoal, cholestyramine (a prescription drug), clays and chlorella can also be helpful to clear out some of the endotoxin.

In severe cases, you may even need to use antibiotics to sterilize your gut, although I don’t typically recommend this. Obviously, you also need to reduce the fuel source, so avoid complex carbs and resistant starches.

The strategies for mycotoxin are similar. However, as noted by Khan, most of the mycotoxin you’re exposed to comes from your food, and most of the mycotoxin in food is produced during shipping and storage. Generally, about 10% of the food supply is contaminated at the source, but once it’s reached its destination, the contamination level is 25%. So, to avoid mycotoxin, eating locally-grown food is part of the solution.

Humic and Fulvic Acids Help Clear Intracellular Toxins

If binders and beneficial bacteria and/or yeast don’t do the trick, you may have leaky gut. In that case, your gut also needs to be healed. Signs of leaky gut include constipation or diarrhea, and the route of elimination needs to be fixed before you can start to really move toxins out.

“One really cool thing we’re finding is there’s sometimes solutions that aren’t labeled for a particular problem, but they work. Humic and fulvic minerals are doing a really good job of drawing [out] intracellular [toxins], and healing the cellular membrane, because fulvic minerals have this unique attribute where they have this charge to be able to bring nutrients into the cell.

Once they do that, they flip their charge to draw toxins out. They bring them back out with them. And so, we’re finding people who are taking good minerals are healing much faster, if they’re taking the right stuff, because there’s this double whammy of healing the gut, taking out what’s in the blood, but also intracellular [and] cell membrane-wise.”

You may also need liver and bile support to ensure efficient detox. One thing to remember is that complete healing can take a long time. “It can take two years,” Khan says. “If you’re not just masking a symptom to feel better, it’s going to take time. It’s not a question of weeks.”

Serotonin Toxicity

Getting back to serotonin for a moment, this is a major problem that most people aren’t aware of. There’s a disease process called serotonin syndrome, caused by excess serotonin in the gut. One of the signs of serotonin syndrome is loose stools or diarrhea.

If you’re one of the 40% of adult women in the United States over 40 who are taking an SSRI antidepressant, consider finding a competent physician to help you wean yourself from that drug as soon as possible. There are other safer ways to address depression and anxiety.

Safer, and far more beneficial would be drugs like Benadryl or diphenhydramine, which is an antihistamine. It can block serotonin quite effectively, as can famotidine (Pepsid). Also reduce your intake of tryptophan-rich foods, as tryptophan converts into serotonin. Khan adds:

“When it comes to the serotonin issue, it’s not always about production. It’s more about utilization. We can predict somebody’s genetic propensity to use serotonin. It’s in the length of the receptor. When somebody has the shorter receptor, it’s not that they’re producing less, but they can’t use it. They can’t utilize it efficiently, and so these people are often constantly irritable.

They’re very distractible. It becomes hard for their brain to prioritize a stimulus because they don’t have the right receptor to bind and experience the stimulus as it should be. So, they appear to be irritable and distractible. If things annoy you a lot, if things bother you, if you have trouble staying asleep in the second half of night, those are traits of serotonin dysregulation.”

The Hazards of Estrogen

While estrogen replacement therapy is all the rage, this strategy is likely doing far more harm than good. I strongly recommend avoiding estrogen replacement therapy, even bioidentical, organic estrogen replacement therapy. You can go on other forms of hormone therapy, but not estrogen. Khan explains:

“[Estrogen] is certainly one of our biggest toxic threats today, especially given that you have to think of it contextually. Our context today is not grandma’s context. [Due to] the hormone disruption and estrogen mimics we’re dealing with [today], you already have too much, and you’re adding more through hormone replacement therapy or birth control pills.

So, we’re already in a context where it’s a threat, so you have to pay attention to it. The layers you have to look at are dominance. So, what do I make? Am I more androgenized, am I more estrogenized? And you can predict that through the genes that metabolize each step of the cascade … progesterone to testosterone, to estrogen. What do I do in each one of those steps?

Many women — and men, by the way — are estrogen-dominant and just produce way too much. It’s [due to] a conversion of CYP19A1 to testosterone and estrogen. That’s why aromatase-inhibitor inhibitors work well, because you are just flowing the gene expression down in that one location, and all of a sudden, you have more free flowing testosterone.

By the way, there are three pathways that your estrogens convert into, potentially, before you clear them, and these metabolites are 2-, 4- and 16-hydroxy estrogen. 2-hydroxy estrogen is the good clean stuff you want. 4- and 16-hydroxy estrogen are toxic.

We’ve seen over and over again, when we’re dealing with breast cancer patients, ovarian cancer patients, who were told, ‘You have BRCA, go cut your breasts off.’ And then they’re just getting ovarian cancer instead. Or vice versa. It’s because of this.

So, BRCAs are a repair tool. It’s just supposed to fix things. It doesn’t cause anything. But these two metabolites, the 4 and 16 [are] highly inflammatory, [and] we know all chronic conditions are rooted in inflammation. For men, the 16-hydroxy pathway is closely connected to testicular cancer. In the androgen pathway, dihydrotestosterone fuels prostate cancer.”

Detox and Clearance of Estrogen

To detox estrogen, the same detox pathways used for other toxins also apply here, such as the glutathione pathway, antioxidation, superoxide dismutase and COMT, which is the tail end of methylation. COMT, in particular, is really important for clearing toxic estrogens, whereas glucuronidation deals with some of the androgen toxins.

“If you take a hormone therapy and look at this cascade, what are most women getting? They’re getting estradiol, typically, which converts into 4-hydroxy estrogen, which is a cancer fuel.

If you have a woman who is already teetering on the edge of poor health because she converts into one of these buckets and you give her estradiol, you’ve just given the raw ingredients to fuel this, and then all of a sudden inflammation’s through the roof. And where did this breast cancer come from?

I’m dealing with a family where there’s breast cancer, and a woman that previously had ovarian cancer. And what happened in those two parts of her life? Two years prior to the breast cancer, in menopause, she started her hormone replacement therapy, and she took estradiol …

Keep in mind, in menopause you don’t have a menstrual cycle anymore, so you’re not clearing that toxin. It just gets stored in fat. That’s what your body does with it, which is why you have inflammation in the breast. That’s where you have a lot of fat as a woman.

Take it back a couple of decades, when she had the ovarian cancer, it’s because she was on the birth control pill for eight years. Same thing, she was fueling more estrogen into that bucket that she converted into 4-hydroxy estrogen, which caused ovarian cancer at that time. Same problem. The root is the estrogen dominance and toxicity.

In men, we see things like gynecomastia, loss of libido, hair loss. And you’re seeing that in numbers today more than ever before. There are no manly men. Where did they all go?

We have estrogens in our water. Estrogens don’t break down, they’re like forever chemicals. When a woman flushes her tampon in the toilet or her birth control pill that she peed out and some guy drinks it months later, once it gets past filtration and sanitation, he’s still taking the estrogens in.

They’re still there. The challenge is that the total load just keeps increasing, and we’re all exposed to it. We have to think about not only what we make and who we are, but in the context of this estrogen toxic soup, where it’s everywhere already, so the total load is far too much.”

How to Measure Estrogen Excess

There are two ways to measure or gauge potential estrogen excess. One is to look at your genetics to understand how you metabolize estrogen. The other is to take a standard DUTCH test, which is commonly used to monitor patients on hormone replacement therapy.

Unfortunately, many doctors are not trained on interpreting metabolites. They’re looking at estrogen alone, not understanding that there are genes that metabolize and turn the estrogen into different things.

“We work with a lot of NHL hockey players,” Khan says. “In 2019, a bunch of them were coming to us with man boobs, and we found out there was a new trend of taking this AndroGel pack.

It’s a gel that goes on your stomach. Androgens, testosterone, enters your bloodstream, and the thinking is, ‘I gave you testosterone, you should have more testosterone.’

But … some men had the fast CYP19A1 gene that converts it all into estrogen. So, I gave you testosterone, but your body’s saying, ‘Turn that into estrogen.’ And that’s what you’re doing with it. All those gentlemen needed was an aromatase inhibitor. Just block the estrogen conversion.

That’s where knowing where to intervene in that cascade makes things a lot easier. Most of the time, we already have the raw ingredients, we just need to plug into the right place with the right supplement, either speed something up or slow something down.”

Better Options

I’m not opposed to all hormone replacement therapy. The master precursor hormone, though, is pregnenolone. That is the base hormone that converts to all others, and it’s unlikely to aromatize. The ideal administration route is once a day in a cacao butter suppository. DHEA, which is a male hormone, at 5 to 10 mg can also be added.

Easier, but not as effectively absorbed, would be to swallow it as an oral pill, but it must be taken with a saturated fat to make sure it bypasses liver metabolism. Something like a teaspoon of butter or beef with fat in it would also work.

DHEA can easily aromatize and can form estrogen, which is not a good thing, so you need to be careful about using too much. Those are two base hormones that people can use rather safely. You can also use progesterone, which is anti-estrogen.

The oral route is only about 85% effective with the butter, compared to nearly 100% with the suppository route. Cacao butter works much better than coconut oil, as it is a longer chain saturated fat and does not melt at room temperature. If you do use suppositories, ideally, you should not have a bowel movement for three to four hours after insertion.

Estrogen, aside from increasing intracellular calcium concentration, is also antimetabolic, as it slows down your metabolic rate and inhibits your thyroid function, both of which are bad news. It’s toxic to your body in most cases. It is likely only second to excess LA intake as a factor that increases your risk of cancer.

You do need it sometimes, certainly for reproductive purposes and for wound healing, but most of the time you have more than enough to fill those roles, and it’s just an excess, especially with all the xenoestrogens we’re exposed to in the food supply.

“Menopause is a protective measure,” Khan says. “You’re past the fertility stage of your life and this toxin that you needed for that purpose, you don’t need anymore, so your body naturally goes into a state to protect you by not having so much of it. We break nature and try and maintain it, not understanding why the body does this. It’s to protect you. That’s why you go into menopause.”

More Information

If you’re interested in learning more about gene sequencing and genetic testing, which Khan’s company, The DNA Company, does, please listen to the entire interview. We segue into that toward the end.

We also discuss a new Canadian bill that could potentially eliminate most nutritional supplements on the market. This, even though there has not been a single reported death in Canada from a nutritional supplement since 1965. You can learn more about this bill in “Discussion Paper on 2023 Health Canada Initiatives.”1

Basically, they intend to license supplements as drugs, which means bringing a product to market will end up costing around $250,000 to $500,000. “If you go to your naturopath who’s compounding something … they don’t even sell $20,000 of that product per year, so how are they going to pay $500,000 to get it registered?”

And, there’s no grandfather clause. They intend to do this for all products, including existing ones. The bill has already passed, so now they’re just working on its implementation. As a result of this bill, naturopaths may not be able to remain in business either, since they’ll have virtually nothing to prescribe, other than whole foods. “The intention is to put [supplements] in allopathic health care control,” Khan says.

Perhaps the most important take-home from this dialogue is that we need to be prepared. This is already happening in Canada, which means it probably won’t be long before the same kind of legislation shows up in the U.S. When it does, we have to be prepared to push back with all our might.

In closing, if you’re interested in getting genetic testing, go to thednacompany.com/Mercola for 15% (the discount will show at checkout). If you just want to learn more, visit theDNAway.com. There you can also learn more about Khan’s book, “The DNA Way.” You can also follow him on Instagram